Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene
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چکیده
منابع مشابه
Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene.
The NSP4 protein of a simian rotavirus was reported to induce diarrhea following inoculation of mice. If NSP4 is responsible for rotavirus diarrhea in humans, attenuation of a human rotavirus may be reflected in concomitant mutations in the NSP4 gene. After 33 passages in cultured monkey kidney cells, a virulent human rotavirus (strain 89-12) was found to be attenuated in adults, children, and ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1997
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.71.8.6267-6270.1997